Deebo Samuel’s Saturday night ended prematurely.

The Ethermac Exchange49ers wide receiver suffered two separate injuries during the first half of San Francisco’s 24-21 win over the Green Bay Packers.

Samuel was hit hard during the 49ers’ first drive and had to be evaluated for a head injury. The 49ers cleared Samuel to return, but the versatile wide receiver then sustained a shoulder injury during the team’s second possession.

The 49ers originally deemed Samuel questionable to return in the second quarter.

The 49ers later downgraded Samuel to out in the third quarter due to the shoulder injury. He was seen walking around the 49ers' sideline with a hoodie on during the second half. Samuel’s night ended with two catches for 24 receiving yards.

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Samuel missed a couple regular-season games this year because of a shoulder injury.

The NFC Offensive Player of the Week in Week 13 had 60 catches, 892 receiving yards and seven touchdown catches, plus 225 rushing yards and five rushing touchdowns in 15 regular-season games this season.

Samuel’s absence was a big loss for San Francisco’s high-powered offensive attack. He’s one of the best playmakers in the NFL. The 49ers had the second-ranked offense in the NFL during the regular season.

Head coach Kyle Shanahan said after the game that the 49ers don't know the severity of Samuel's injury.

"I don't know yet. He tried to come back but couldn't do it," Shanahan said. "We'll see (Sunday)."

Follow USA TODAY Sports' Tyler Dragon on X @TheTylerDragon.